By Lazaros C. Triarhou
This publication is the fruits of fifteen years of study at the transplantation of dopaminergic neurons within the striatum of the weaver mouse (wv/wv), a neurological mutant characterized
through genetically-determined degeneration of midbrain dopamine neurons. This mutant constitutes the single to be had laboratory version with a prolonged disease that mimics Parkinson's sickness. Structural and practical facets of
intrastriatal mesencephalic neuron grafting into the weaver version are reviewed, together with histochemical correlates of graft survival and integration, numerical features of donor telephone survival, ultrastructural findings on
synaptogenesis, neurochemical indices of dopamine uptake and receptor binding, gene expression of structural and neurotransmitter-receptor comparable molecules, degrees of striatal amino acid receptors, and behavioural results of
unilateral and bilateral neuronal transplantations.
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Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease (Advances in Experimental Medicine and Biology) by Lazaros C. Triarhou
by Anthony
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